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- OBJECTIVE: To assess the comprehensiveness of Medline and Embase computer
- searches for controlled trials. DESIGN: Comparison of articles found after
- an exhaustive search of the literature with the yield of a Medline or
- Embase search. This was performed for controlled clinical trials on the
- efficacy of three interventions: homoeopathy, ascorbic acid for common
- cold, and ginkgo biloba for intermittent claudication and cerebral
- insufficiency. The number of controlled trials found by exhaustive search
- of the literature was 107, 61 and 45, respectively. RESULTS: For
- homoeopathy, ascorbic acid and ginkgo the proportion of all trials found by
- Medline was 17%, 36% and 31% respectively and for Embase 13%, 25% and 58%
- respectively. After checking of the references in the Medline articles 44%,
- 79% and 76% of all trials were identified. After checking of the references
- in the Embase articles 42%, 72% and 93% of all trials were identified.
- About 20% of the articles was not correctly indexed. Of the best trials
- 68%, 91% and 83% could be found with Medline and 55%, 82% and 92% of the
- best trials were identified through Embase. CONCLUSIONS: For the topics
- mentioned, Medline and Embase searches are sufficient to get an impression
- of the evidence from controlled trials, but only if references in the
- articles are followed for further evidence. If one wants to get a more
- complete picture, additional search strategies make sense. Of course, this
- picture may be different for other topics.
-